Contacts

Kelso scaled 260 300

A/Prof Michael J Kelso  

B.Med. Chem. (Hons 1), University of Wollongong, 1996 (University Medal for the Faculty of Science)
Ph.D., Institute for Molecular Bioscience, University of Queensland, 2002 (with Professor David Fairlie) 

Email:        mkelso@uow.edu.au
Phone:     +61 2 4221 5085
Office:       B18.115

Position     
  • Associate Professor

Research Interests

Medicinal chemistry, drug design and synthesis, structure-based drug design, prodrug design and synthesis, antitumour agents, antimicrobial agents, biofilm dispersing agents, organic synthesis.


Recent Publications
  1. Attaching the NorA Efflux Pump Inhibitor INF55 to Methylene Blue Enhances Antimicrobial Photodynamic Inactivation of Methicillin-Resistant Staphylococcus aureus in vitro and in vivo. Rineh, R.; Dolla, N. K.; Ball, A. R.; Magana, M.; Bremner, J. B.; Hamblin, M. R.; Tegos, G. P.; Kelso, M. J. ACS Infect. Dis. 2017, 3, 756-766.
  2. Low dose nitric oxide as targeted anti-biofilm adjunctive therapy to treat chronic Pseudomonas aeruginosa infection in cystic fibrosis. Cathie, K.; Howlin, R. P.; Hall-Stoodley, L.; Cornelius, V.; Duignan, C.; Allan, R.; Feelisch, M.; Fernandez, B. O.; Barraud, N.; Bruce, K.; Jefferies, J.; Kelso, M. J.; Kjelleberg, S.; Rice, S.; Rogers, G.; Pink, S.; Smith, C.; Sukhtankar, P.; Salib, R.; Legg, J.; Carroll, M.; Daniels, T.; Stoodley, P.; Clarke, S.; Connett, G.; Faust, S. N.; Webb, J. Mol. Ther. 2017, 25, 1-13.
  3. Primary Ciliary Dyskinesia Ciliated Airway Cells Are Susceptible to Haemophilus influenzae Biofilm Formation. Walker, W. T.; Jackson, C. L.; Allan, R. N.; Collins, S. A.; Kelso, M. J.; Rineh, A.; Yepuri, N. R.; Nicholas, B.; Lau, L.; Johnson, D.; Lackie, P.; Faust, S. N.; Lucas, J. S. A.; Hall-Stoodley, L. Eur. Respir. J. 2017; 50: 1700612.
  4. Activity of a novel protonophore against methicillin-resistant Staphylococcus aureus. Tharmalingam, N.; Jayamani, E.; Rajamuthiah, R.; Castillo, D.; Fuchs, B. B.; Kelso, M. J.; Mylonakis, E. Future Med. Chem. 2017, 9, 1401-1411.
  5. Unexpected synthesis of 3-imino-2-(pyrrol-2-yl) isatogen derivatives affords facile access to a 2-pyrrolyl isatogen. Kirk, N. S.; Sansom, G. N.; Sudta, P.; Suksamrarn, S.; Willis, A. C.; Bremner, J. B,; Kelso, M. J. Synthetic Commun. 2017, 47, 62–67.
  6. Cephalosporin-3’-Diazeniumdiolate NO Donor Prodrug PYRRO-C3D Enhances Azithromycin Susceptibility of Non-typeable Haemophilus influenza Biofilms. Collins, S. A.; Kelso, M. J.; Rineh, A.; Yepuri, N. R.; Coles, J.; Jackson, C. L.; Halladay, G. D.; Walker, W. T.; Webb, J. S.; Hall-Stoodley, L.; Connett, G. J.; Feelisch, M.; Faust, S. N.; Lucas, J. S. A.; Allan, R. N. Antimicrobial Agents and Chemother. 2017, 61(2) e02086-16/1-e02086-16/12.
  7. Cephalosporin-NO-donor prodrug PYRRO-C3D shows β-lactam-mediated activity against Streptococcus pneumoniae biofilms. Allana, R. N.; Kelso, M. J.; Rineh, A.; Yepuri, N. R.; Feelisch, M.; Soren, O.; Brito-Mutunayagama, S.; Saliba, R. J.; Stoodley, P.; Clarke, S. C. Webb, J. S.; Hall-Stoodley, L.; Faust, S. N. Nitric Oxide 2017, 65, 43–49.
  8. Determination of Ester Position in Isomeric (O-acyl)-hydroxy Fatty Acids by Ion Trap Mass Spectrometry. Marshall, D. L.; Saville. J. T; Maccarone, A. T.; Ailuri, R.; Kelso, M. J.; Mitchell, T. W.; Blanksby, S. J. Rapid Commun. Mass Spectrom. 2016, 30, 2351–2359.
  9. Johnston, T.; Hendricks, G. L.; Shen, S.; Chen, R. F.; Kwon, B; Kelso, M. J.; Kim, W.; Fuchs. B. B.; Mylonakis, E. Raf-kinase inhibitor GW5074 shows antibacterial activity against methicillin-resistant Staphylococcus aureus and potentiates the activity of gentamicin. Future Med. Chem. 2016, 8, 1941–1952.
  10. 5′-Substituted Amiloride Derivatives as Allosteric Modulators Binding in the Sodium Ion Pocket of the Adenosine A2A Receptor. Massink, A.; Louvel, J.; Adlere, I.; van Veen, C.; Huisman, B. J. H.; Dijksteel, G. S.; Guo,D.; Lenselink, E. B.; Buckley, B. J. ; Matthews, H.; Ranson, M.; Kelso, M. J.; Ijzerman, A. P. J. Med. Chem. 2016, 59, 4769−4777.
  11. Kirk, N. S.; Bezos, A.; Willis, A. C.; Sudta, P.; Suksamrarn, S.; Parish, C. R.; Ranson, M.; Kelso, M. J. Synthesis and Preliminary Evaluation of 5,7-Dimethyl-2-aryl-3Hpyrrolizin-3-ones as Angiogenesis Inhibitors. Bioorg. Med. Chem. Lett. 2016, 26, 1813−1816.
  12. Nitric Oxide: A Key Mediator of Biofilm Dispersal with Applications in Infectious Diseases. Barraud, N.; Kelso, M. J; Rice, S. A.; Kjelleberg, S. Curr. Pharm. Des. 2015, 21, 31−42.
  13. Bacterial Sliding Clamp Inhibitors that Mimic the Sequential Binding Mechanism of Endogenous Linear Motifs. Yin, Z.; Whittell, L. R.; Wang, Y.; Jergic, S.; Ma, C.; Lewis, P. J.; Dixon, N. E.; Beck, J. L.; Kelso, M. J.; Oakley, A. J. J. Med. Chem. 2015, 57, 4693−4702.
  14. Antibacterial Properties of 3-(phenylsulfonyl)-2-pyrazinecarbonitrile. Rajamuthiah, R.; Jayamani, E.; Majed, H.; Conery, A. L.; Kim, W.;Kwon, B.; Fuchs, B. B.; Kelso, M. J.; Ausubel, F. M.; Mylonakis, E. Bioorg. Med. Chem. Lett. 2015, 25, 5203−5207.
  15. Helical Cyclic Pentapeptides Constrain HIV-1 Rev Peptide for Enhanced RNA Binding. Harrison, R. S.; Shepherd, N. E.; Hoang, H. N.; Beyer, R. E.; Ruiz-Gómez, G.; Kelso, M. J.; Kok, W. M.; Hill, T. A.; Abbenante, G.; Fairlie, D. P. Tetrahedron 2014, 70, 7645-7650.
  16. Clostridium difficile Infection: Molecular Pathogenesis and Novel Therapeutics. Rineh, A.; Kelso, M. J.; Vatansever, F.; Tegos, G. P.; Hamblin, M. R. Expert. Rev. Anti. Infect. Ther. 2014, 12, 131‒150.
  17. On the Mechanism of Berberine-INF55 (5-Nitro-2-Phenylindole) Hybrid Antibacterials. Dolla, N. K.; Chen, C.; Larkins-Ford, J.; Rajamuthiah, R.; Jagadeesan, S.; Conery, A. L.; Ausubel, F. M.; Mylonakis, E.; Bremner, J. B.; Lewis, K.; Kelso, M. J. Aust. J. Chem. 2014, 67, 1471.
  18. Discovery of Lead Antibacterials Targeting the E. coli Sliding Clamp using a Fragment-Based Approach. Yin, Z.; Whittell, L. R.; Wang, Y.; Jergic, S.; Liu, M.; Harry, E. J.; Dixon, N. E.; Beck, J. L.; Kelso, M. J.; Oakley, A. J. J. Med. Chem. 2014, 57, 2799-2806.
  19. DNA Replication is the Target for the Antibacterial Effects of Non-Steroidal Anti-Inflammatory Drugs. Yin, Z.; Wang, Y.; Whittell, L. R.; Jergic, S.; Liu, M.; Harry, E. J.; Dixon, N. E.; Kelso, M. J.; Beck, J. L., Oakley, A. J. Chem. Biol. 2014, 21, 481-487.
  20. Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells. Chen, C.; Dolla, N. K.; Casadei, G.; Bremner, J. B.; Lewis, K.; Kelso, M. J. Bioorg. Med. Chem. Lett. 2014, 24, 595-600.
  21. Structural and Thermodynamic Dissection of Linear Motif Recognition by the E. coli Sliding Clamp. Yin, Z.; Kelso M. J.; Beck, J. L.; Oakley, A. J. J. Med. Chem. 2013, 56, 8665-8673.
  22. A Comparison of Patient Matched Meibum and Tear Lipidomes. Brown, S. H. J.; Kunnen, C. M. E.; Duchoslav, E.; Dolla, N. K.; Kelso, M. J.; Papas, E. B.; de la Jara, P. L.; Willcox, M. D. P.; Blanksby, S. J.; Mitchell, T. W. Invest. Ophthalmol. Vis. Sci. 2013, 54, 7417-7423.
  23. Synthesis, Structural Characterisation and Preliminary Evaluation of Non-Indolin-2-one-Based Angiogenesis Inhibitors Related to Sunitinib (Sutent®). Sudta, P.; Kirk, N.; Bezos, A.; Gurlica, A.; Mitchell, R.; Weber, T.; Willis, A. C.; Prabpai, S.; Kongsaeree, P.; Parish, C. R.; Suksamrarn, S.; Kelso, M. J. Aust. J. Chem. 2013, 66, 864–873.
  24. Synthesis of Cephalosporin-3′-Diazeniumdiolates: Biofilm Dispersing NO-Donor Prodrugs Activated by b-Lactamase. Yepuri, N. R.; Barraud, N.; Mohammadi, N. S.; Kardak, B. G.; Kjelleberg, S.; Rice, S. A.; Kelso, M. J. Chem. Commun. 2013, 49, 4791-479.

Current Group Members

Postdoctoral Fellows

  • Dr Ardeshir Rineh: Synthesis of NO donor (β)-lactam antibiotics
  • Dr Ramesh Ailuri: Synthesis and Biophysical Properties of Unusual Lipids found in Human Tears
  • Dr Benjamin Buckley: Novel analogues of amiloride as anti-tumour/metastasis agents
  • Dr Ashraf Aboelela: Amiloride analogues as new agents against multidrug resistant (MDR) tuberculosis 

PhD Students

  • Hiwa Majed: Synthesis and evaluation of novel agents against Staphylococcus aureus and Mycobacterium tuberculosis
  • Geraud Sansom: Kinase inhibitor-Cytotoxin mutual prodrugs activated by tumour hypoxia
  • Nehad Elsalamouny: Molecular simulations with the urokinase plasminogen activator (uPA) and sodium hydrogen exchanger type I (NHE1)
  • Richard Bujaroski: Amiloride analogues as new agents against multidrug resistant (MDR) tuberculosis
  • Phill Cantrell: The role of calcium in general anaesthesia

Honours Students

  • Katherine Wright: Synthesis of NO donor -lactam antibiotics

 Abbreviated CV

Academic Qualifications

  • B.Med. Chem. (Hons 1), University of Wollongong, 1996 (University Medal for the Faculty of Science)
  • Ph.D., Institute for Molecular Bioscience, University of Queensland, 2002 (with Professor David Fairlie)

Positions held

  • Associate Professor, School of Chemistry, University of Wollongong, Australia, January 2015 – current
  • Senior Lecturer, School of Chemistry, University of Wollongong, Australia. January 2010 - 2014
  • Lecturer, School of Chemistry, University of Wollongong, Australia.  January 2008-2009
  • NHMRC CJ Martin Research Fellow, School of Chemistry, University of Wollongong, Australia. January 2006 - January 2008
  • NHMRC CJ Martin Research Fellow, Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA (with Professor Dale Boger) January 2004 - December 2005
  • Postdoctoral Research Fellow, Universidad del Pais Vasco, San Sebastian, Spain (with Professor Claudio Palomo and Professor Mikel Oiarbide) December 2002 - December 2003
  • Postdoctoral Research Fellow, Institute for Molecular Bioscience, University of Queensland (with Professor David Fairlie) March 2002 - November 2002. 

 

Last reviewed: 7 December, 2017