School of Chemistry

ROBERT GLASER

Personal :

Date & Place of Birth: March 17th, 1942; New York, NY

Address: Department of Chemistry, Ben-Gurion University of the Negev

Beer-Sheva 84105, Israel

Office Telephone: +972-(0)8-646-1194 Home Telephone: +972-(0)8-646-9812

FAX: +972-(0)8-690-0084 Cellular: +972-(0)52-276-3954

EMAIL: rglaser@bgu.ac.il

Nationality: Israeli and American Military Service: I.D.F., Captain (Ret.)

Academic Positions:

1971-to date Ben-Gurion University of the Negev, Beer-Sheva, Israel

Department of Chemistry; Full Professor (1997), Associate Professor (1989), Senior Lecturer (1977), Lecturer (1971)

1995-1996 Institute for Advanced Studies at the Hebrew University of Jerusalem

Institute Fellow, study project on Chirality and Chiral Drugs.

1988-1998 Weizmann Institute of Science, Rehovot, Israel

Feinberg Graduate School, Visiting Professor concurrent with my duties at Ben-Gurion University. Advanced Stereochemistry, Computer Assisted Molecular Modeling, Advanced Nuclear Magnetic Resonance Spectroscopy Courses.

Visiting Professorships:

Jul 2007 European School on Solid-State NMR: 2nd Advanced School – Materials Science Applications, Safed, Israel

Jul 2006 Universidade Federal do Rio de Janiero, Rio de Janiero, Programa de Pós-Graduacão em Química Orgãnica, Instituto de Química.

'Special Topics in Advanced Stereochemistry and Introduction to Solid-State NMR'

mini-course (Prof. D. Azevedo and Prof. C. Kaiser).

Jun 2006 Universidad Autónoma Nacional de México, Mexico City, Instituto de Química, Programa de Postgrado en Química, Mexico City, D.F., Mexico, Instituto

de Química.

'Special Topics in Advanced Stereochemistry and Introduction to Solid-State NMR'

mini-course (Prof. G. Delgado).

Feb 2006 University of Mandalay, Mandalay, Myanmar, Department of Chemistry

'Special Topics in Advanced Stereochemistry’ mini-course (Prof. T. Win).

Feb 2005 Universidad de Costa Rica, San José, Costa Rica, Programa de Postgrado en

Química.

'Special Topics in Advanced Stereochemistry and Introduction to Solid-State NMR'

mini-course (Prof. R. Romero).

Sept 2004 Johannes Kepler Universität, Linz, Austria, Institut fuer Organische Chimie

'Special Topics in Advanced Stereochemistry and Introduction to Solid-State NMR'

mini-course (Prof. N. Müller).

Feb 2004 Universidad Autónoma Nacional de México, Mexico City, D.F., Mexico, Instituto

de Química.

'Special Topics in Advanced Stereochemistry and Introduction to Solid-State NMR'

mini-course (Prof. G. Delgado & Prof. E. Juaristi).

Oct 2003 Universidade Federal do Fluminense, Rio de Janiero, Brasil, Departamento de

Química. 'Special Topics in Advanced Stereochemistry and Introduction to Solid-

State NMR'mini-course (Prof. P. Siedl & Prof. K. Leal).

Nov-Dec 2002 University of Wollongong, Wollongong, Australia, Department of Chemistry

Medicinal Chemistry course 'From Gene to Drug' (Prof. J. Bremner).

Oct-Nov 2002 University of Auckland, Auckland, New Zealand, 'Mid-term guest'.

Quantum mechanical calculations of NMR spin-spin coupling constants

(Prof. P. Schwerdtfeger).

Jul/Aug 2002 Syracuse University, Syracuse, New York, Department of Chemistry

Jan/Feb 2003 Advanced Stereochemistry Course (in two parts); and NMR

Spectroscopy course (Prof. J. Baldwin).

March 1999 Universiteit Twente, Enschede, Holland, Department of Supramolecular Chemistry Advanced Stereochemistry Course (40 hours) (Prof. D. Reinhoudt).

Summer 1995 University of Wollongong, Wollongong, Australia, Department of Chemistry

Stereochemistry (Prof. J. Bremner).

Summer 1989 University of Bergen, Bergen, Norway, Department of Chemistry

X-ray crystallography (Dr. K. Maartmann-Moe).

Summer 86-87 McGill University, Montréal, Canada, Department of Chemistry

High-field NMR Analysis of Oligo- and Monosaccharides (Prof. A. S. Perlin).

Summer l985 Stanford Research Institute, Menlo Park, CA, Physical-Organic Chemistry Department, Polysilazane chemistry (Dr. R. M. Laine) and Molecular mechanics calculations (Dr. G. H. Loew).

Summer 1984 Ohio State University, Columbus, OH, Department of Chemistry

Inorganic stereochemistry (Prof. D. W. Meek).

Summer 1983 University of California at San Diego, La Jolla, CA, Department of Chemistry

Protein stereochemistry (Prof. M. Goodman).

1982-1983 Ohio State University, Columbus, OH, Department of Chemistry

P-31 & Pt-195 NMR (Prof. D. W. Meek).

1978-1979 Princeton University, Princeton, NJ, Department of Chemistry

Stereochemistry (Prof. K. Mislow).

Summer 1978 University of Oxford, Oxford, UK, Dyson Perrins Laboratory

31P NMR spectroscopy (Prof. J. M. Brown).

Research Interests:

Organic and inorganic stereochemistry; molecular modeling, computer assisted drug design, structure determination via NMR spectroscopic techniques; solid-state 13C CP-MAS NMR studies on drug polymorphism; hormone/receptor and drug receptor interactions; conformational/configurational ambiguity in pharmacologically-active molecules; multinuclear NMR; 2D-NMR techniques, development of CAI animated teaching programs for stereochemistry.

Education:

1970-1971 Princeton University, Princeton, NJ, Department of Biochemical Sciences

Postdoctoral Research Fellow (Prof. R. Langridge) X-ray crystallography.

1969-1970 Princeton University, Princeton, NJ, Department of Chemistry

Postdoctoral Research Fellow (Prof. P .v. R. Schleyer) Adamantane chemistry.

1966-1969 Rutgers University, New Brunswick, NJ, Department of Chemistry

Polynucleotide-polyammonium cation interactions (Prof. E. J. Gabbay)

Ph.D. (Bio-organic Chemistry), February 1970.

1963-1965 Polytechnic Institute of Brooklyn, New York, NY, Department of Chemistry,
part-time M. Sc. student, polymer chemistry.

1959-1963 University of Pennsylvania, Philadelphia, PA, Department of Chemistry,

B.A. (Chemistry), June 1963.

Other Employment:

Summer 1991 Ciba-Geigy AG [now Novartis], Basel, CH, Computer Assisted Molecular Modeling Unit Determination of a common bioactive conformational model for a polypeptide and two families of small target molecules (Dr. N. C. Cohen).

Summer 1990 Nova Pharmaceutical Co. Inc., Baltimore, MD, CNS Department (Dr. C. Kaiser) in collaboration with The Johns Hopkins University, Baltimore, MD, Department of Neuroscience (Prof. S. Snyder)

Receptor structural requisites for a series of neuroleptic drugs.

Summer 1988 Merck Frosst Centre for Therapeutic Research, Montreal, Québec, Canada, Medicinal Chemistry Department

High field NMR spectroscopy and stereochemistry (Dr. M. Bernstein).

1963-1966 PPG Industries Inc., Adhesive Products Division, Bloomfield, NJ

Development chemist of neoprene and epoxy industrial adhesives.

1959-1961 E. R. Johnson Foundation for Experimental Biology, University of Pennsylvania, Philadelphia, PA

Electronics technician for in-house construction of a T(temperature)-jump prototype apparatus (Dr. G. Czerlinski).

Awards, Honors, and Competitive Research Fellowships:

1995-1996 Israel Institute for Advanced Studies at the Hebrew University

Institute Fellow in study project on Chirality and Chiral Drugs

1969-1971 United States Department of Health, Education, and Welfare, National Institutes of Health

Two-year Postdoctoral Fellowship Competition Winner on original research proposal: "Interaction of Polynucleotide Double-Helices with Adamantyl Diammonium Salts"–Postdoctoral Studies

1966-1969 United States National Defense Education Act, Title IV

Three-year Predoctoral Fellowship Competition Winner–Graduate Education

1959-1963 New York State Regents College Scholarship
Four-year Undergraduate Scholarship
Competition Winner–Undergraduate Studies

Industrial Consultantships:

1980; 2001-to-2000 Dead Sea Bromine Compounds Ltd., Beer-Sheva, Israel

1992-1994; 1996-to 2000 Makhteshim Chemical Works Ltd., Beer-Sheva, Israel

2000-to date ChemAgis Ltd., Ramat Hovav, Israel

1994-to date Teva Pharmaceutical Industries Ltd., Jerusalem/Petach Tikvah, Israel

List of Publications:

(a) Invited Reviews and Chapters:

1. "Some Illustrative Examples of Methodology For Configurational and Conformational Assignment of Disaccharide Stereochemistry."

Glaser, R. In Polysaccharides from Microalgae: A New Agroindustry, Ramus, J., Jones, M. C., Eds.; Duke University Marine Laboratory: Beaufort, NC; 1988, pp 98-109.

2. "Synthetic Routes to Oligo- and Polysilazanes. Polysilazane Precursors to Silicon Nitride."

Laine, R. M.; Blum, Y. D.; Tse, D. S.; Glaser, R. in ACS Symposium Series, vol. 360; American Chemical Society: Washington, 1988; pp 124-142.

3. "Production and Characterization of Polysaccharides in the Unicellular Red Alga Rhodella Reticulata."

Dubinsky, O.; Lerental (Brown), Y.; Christiaen, D.; Glaser, R.; Barak, Z.; Arad (Malis), S. in Algal Biotechnology; Stadler, T., Mollion, J., Verdus, M. C., Karamanos, Y., Morvan, H., Christiaen, D., Eds.; Elsevier Applied Science: London, 1988; pp 451-461.

4. "Cannabinoids: Differential Stereochemical Requirements for Cannabimimetic and Therapeutic Activity."

Mechoulam, R.; Feigenbaum, J. J.; Breuer, A.; Zahalka, J.; Lander, N.; Järbe, T. U. C.; Hiltunen, A. J.; Glaser, R. in Trends in Medicinal Chemistry '88; van der Goot, H., Domány, G., Pallos, L., Timmerman, H., Eds.; Elsevier Science Publishers: Amsterdam, 1989, pp 467-481.

5. "Triarylamine Stereochemistry and Correlated Motion in the Three-Bladed Propeller."

Glaser, R. in Acyclic Organonitrogen Stereodynamics; Lambert, J. B., Takeuchi, Y., Eds.; VCH: New York, 1992, pp. 123-148.

6. "Cannabinoid Geometry and Biological Activity."

Mechoulam, R.; Devane, W. A.; Glaser, R. in Marijuana/Cannabinoids: Neurobiology and Neurophysiology; Murphy, L., Bartke, A., Eds.; CRC Press: Boca Raton, 1992, pp 1-33.

7. "11C-Nefopam as a Potential PET Tracer of Serotonin Reuptake Sites: Initial Findings in Living Pig Brain."

Smith, D. F.; Glaser, R.; Gee, A.; Gjedde, A. in Quantification of Brain Function using PET; Myers, R., Cunningham, V. J., Bailey, D. L., Jones, T., Eds.; Academic Press: San Diego, 1996, pp 38-41.

8. "Cannabinoid Geometry and Biological Activity."

Mechoulam, R.; Devane, W. A.; Glaser, R. in Marihuana and Medicine; Nahas, G. G., Sutin, K. M., Harvey, D., Agurell, S., Eds.; Humana Press: Totowa, NJ, 1999, pp 65-90.

(b) Patents and Miscellaneous:

9. "Neoprene Based Adhesives."

Spector, S.; Grover, M. M.; Glaser, R. U.S. Pat. 3,595,821, July 27, 1971.

10. "Selective Interactions of Nucleic Acids."

Glaser, R. Ph.D. Dissertation, Rutgers University: New Brunswick, NJ; 1970.

(c) Refereed Publications In Scientific Journals:

11. "Interactions of Spermine and Spermidine Derivatives with Polyadenylic-Polyuridylic and Polyinosinic-Polycytidylic Acid Helices."

Glaser, R.; Gabbay, E. J. Biopolymers 1968, 6, 243.

12. "A Nuclear Magnetic Resonance Study of the Interactions of Reporter Molecules with Deoxyribonucleic Acid. Evidence for Hydogen-Bonding Interactions."

Gabbay, E. J.; Gaffney, B. L.; Glaser, R.; Denney, D. Z. J. Chem. Soc., Chem. Commun. 1969, 1507.

13. "Synthesis and Characterization of C3 and C17 Steroidal Amines."

Glaser, R.; Gabbay, E.J. J. Org. Chem. 1970, 35, 2907.

14. "Comparative Studies of the Interactions of Aliphatic Diammonium Salts with Double- and Triple-stranded Deoxyribohomopolymers, Hybrid Homopolymers, and Ribohomopolymers."

Gabbay, E. J.; Glaser, R. Biochim. Biophys. Acta 1970, 224, 272.

15. "Interaction Specificity of Nucleic Acids."

Gabbay, E. J.; Glaser, R.; Gaffney, B.L. Ann. New York Acad. Sci. 1970, 171, 810.

16. "Proton Magnetic Resonance Studies of the Interaction Specificities of Steroidal Amines with Nucleic Acid Systems."

Gabbay, E. J.; Glaser, R. Biochemistry 1971, 10, 1665.

17. "Synthesis of 1,2- and 2,4-Disubstituted Adamantanes. The Protoadamantane Route."

Lenoir, D.; Glaser, R.; Mison, P.; Schleyer, P. v. R. J. Org. Chem. 1971, 36, 1821.

18. "Prediction of Chirality of Major Products by Models of DIOP−Rhodium(I) Complexes for Asymmetric Hydrogenation and Hydrosilylation."

Glaser, R. Tetrahedron Lett. 1975, 2127.

19. "NMR Determination of E,Z-Geometry in Prochiral Substrates used in Asymmetric Hydrogenation Reactions: α-Acetamidocinnamic Acids, Esters, and Parent Azlactones."

Glaser, R.; Twaik, M. Tetrahedron Lett. 1976, 1219.

20. "Small Scale Method for Fresh Preparation of Cationic DIOP−Rhodium(I) Complexes and Comparison with Neutral DIOP−Rhodium(I) Complexes."

Glaser, R.; Geresh, S.; Blumenfeld, J. J. Organometal. Chem. 1976, 112, 355.

21. "Use of Z-α-Acetamidocinnamate Esters as Structural Probes for DIOP−Rhodium(I) Complexes."

Glaser, R.; Vainas, B. J. Organometal. Chem. 1976, 121, 249.

22. "Asymmetric Homogeneous Hydrogenation of Z-α-Acetamidocinnamate Esters of Chiral Alcohols with DIOP−Rhodium(I) Complexes and Symmetrical Diphosphine−Rhodium(I) Complexes."

Glaser, R.; Geresh, S.; Blumenfeld, J. Vainas, B.; Twaik, M. Isr. J. Chem. 1976/1977, 15, 17.

23. "Inhibition of the Asymmetric Hydrogenation of Z-Methyl α-Acetamidocinnamate Catalyzed by DIOP−Rhodium(I) Catalyst in the Presence of Z-Adamantyl or Bornyl α-Acetamidocinnamate."

Glaser, R.; Blumenfeld, J. Tetrahedron Lett. 1977, 2525.

24. "Use of Z-methyl α-Acylaminocinnamates as Structural Probes for DIOP−Rhodium(I) Complexes."

Glaser, R.; Geresh, S. Tetrahedron Lett. 1977, 2527.

25. "Asymmetric Hydrogenation of N-Acetyldehydroamino Acids with Rhodium(I) Complexes Containing Chiral Carbocyclic Analogues of DIOP."

Glaser, R.; Twaik, M.; Geresh, S.; Blumenfeld, J. Tetrahedron Lett. 1977, 4635.

26. "Proton-NMR Determination of E,Z-Configuration and Cis,Trans-Amide Conformations in Prochiral Substrates used in Asymmetric Hydrogenation Reactions: Methyl and Ethyl α-Formamido-β-Substituted Acrylates."

Glaser, R.; Geresh, S.; Schöllkopf, U.; Meyer, R. J. Chem. Soc., Perkin I 1979, 1746.

27. "Asymmetric Homogeneous Hydrogenation of Z-N-Acetyldehydroamino Acids and Esters with (1R,2R)-trans-1,2-bis(diphenylphosphinomethyl)cyclobutane/Rhodium(I) Complexes."

Glaser, R.; Blumenfeld, J.; Twaik, M. Tetrahedron Lett. 1977, 4639.

28. "Asymmetric Homogeneous Hydrogenation of Z-α-Acylaminocinnamic Acids and Esters with (1R,2R)-trans-1,2-bis(diphenylphosphinomethyl)cyclohexane/Rhodium(I) Complexes."

Glaser, R.; Geresh, S.; Blumenfeld, J.; Twaik, M. Tetrahedron 1978, 34, 2405.

29. "Steric and Electronic Factors in the Asymmetric Homogeneous Hydrogenation of Z-α Acylaminocinnamic Acids and Esters Catalyzed by Rhodium(I) Complexes of DIOP."

Glaser, R.; Geresh, S. Tetrahedron 1979, 35, 2381.

30. "Asymmetric Hydrogenation Catalyzed by Rhodium Complexes of (2R,4R) Bis(diphenylphosphinomethyl)dioxolan. A Stable Rhodium Dihydride Derived from a Chelating Diphosphine Complex."

Brown, J. M.; Chaloner, P. A.; Descotes, G.; Glaser, R.; Lafont, D.; Sinou, D. J. Chem. Soc., Chem. Commun. 1979, 611.

31. "Intermediates in Asymmetric Hydrogenation. The Structure and 31P NMR Spectra of Rhodium Enamide Complexes Containing (1R,2R)-trans-1,2-Bis(diphenylphosphinomethyl)cyclobutane."

Brown, J. M.; Chaloner, P. A.; Glaser, R.; Geresh, S. Tetrahedron 1980, 36, 815.

32. "Heptagonal Chelating Ring Flexibility in Rhodium(I) Complexes of Trans-1,2- Bis(diphenylphosphinomethyl)cycloalkanes."

Glaser, R.; Geresh, S.; Twaik, M. Isr. J. Chem. 1980, 20, 102.

33. "Separation and Identification of Residual Diastereomers in a Maximally Labeled Triarylamine."

Glaser, R.; Blount, J. F.; Mislow, K. J. Am. Chem. Soc. 1980, 102, 2777.

34. "Asymmetric Homogeneous Hydrogenation of α-Acylaminocinnamic Acids and Esters Catalyzed by a Rhodium(I) Complex of DIOXOP."

Lafont, D.; Sinou, D.; Descotes, G.; Glaser, R.; Geresh, S. J. Mol. Catal. 1981, 10, 305.

35. "Stereochemical Consequences of Chelated, Bridging Phosphino-Phosphido Ligands in Bimetallic Complexes. The Molecular Structure of Both Meso and Sn,Sn- [PtCl{C6H5P(CH2)3P(C6H11)2}]2."

Glaser, R.; Kountz, D. J.; Gallucci, J. C.; Meek, D. W. Inorg. Chim. Acta 1983, 77, L207.

36. "Stereochemical Consequences of Chelated, Bridging Phosphino-Phosphido Ligands in Bimetallic Complexes. Single-crystal X-ray Diffraction and Multinuclear [1H, 31P{1H}, 195Pt{1H} NMR Studies on the Stereochemistry of Dichlorobis[(3-(di(cyclohexyl or phenyl)phosphino)propyl)phenylphosphido]diplatinum(II) Diastereomeric Complexes and their Dipalladium(II) Analogues."

Glaser, R.; Kountz, D. J.; Waid, R. D.; Gallucci, J. C.; Meek, D. W. J. Am. Chem. Soc. 1984, 106, 6324.

37. "Structural and Stereochemical Studies on Reactive Iridium(III) Dihydride Complexes of the Triphosphine Ligand C6H5P[(CH2CH2CH2P(C6H11)2]2."

Yang, C.; Socol, S. M.; Kountz, D. J.; Meek, D. W.; Glaser, R. Inorg. Chim. Acta 1986, 114, 119.

38. "Conformation of Nefopam Hydrochloride, a Novel Analgesic."

Glaser, R.; Cohen, S.; Donnell, D.; Agranat, I. J. Pharm. Sci. 1986, 75, 772.

39. "Bridged Peptides: Synthesis, Spectroscopy, and Computer Simulations."

Manesis, N.; Hassan, M.; Glaser, R.; Goodman, M. Biopolymers 1986, 25, S107.

40. "Stereochemistry of the N-methyl Group in Salts of Tropane Alkaloids."

Glaser, R.; Peng, Q. -J.; Perlin, A. S. J. Org. Chem. 1988, 53, 2172.

41. "1H and 13C NMR Studies on N-Methyl-1-Deoxynojirimycin, an α-D-Glucosidase Inhibitor."

Glaser, R.; Perlin, A. S. Carbohyd. Res. 1988, 182, 169.

42. "Catalytic Synthesis of Oligosilazanes. 2."

Biran, C.; Blum, Y D.; Glaser, R.; Tse, D. S.; Youngdahl, K. A.; Laine, R. M. J. Mol. Catal. 1988, 48, 183.

43. "Stereochemistry and Conformation in Solution of Nefopam Hydrochloride, a Benzoxazocine Analgesic Drug."

Glaser, R.; Frenking, G.; Loew, G. H.; Donnell, D.; Agranat, I. New J. Chem. 1988, 12, 953.

44. "Solid State Stereochemistry of Nefopam Hydrochloride, a Benzoxazocine Analgesic Drug."

Glaser, R.; Frenking, G.; Loew, G. H.; Donnell, D.; Cohen, S.; Agranat, I. J. Chem. Soc., Perkin Trans. 2 1989, 113.

45. "Stereochemistry and Conformation in Solution of Diltiazem Hydrochloride, a 1,5-Benzothiazepine Coronary Vasodilator."

Glaser, R.; Sklarz, B. J. Chem. Soc., Perkin Trans. 2 1989, 1031.

46. "NMR Structure Determination of 3-O-(α-D-Glucopyranosyluronic Acid)-L-Galactopyranose, An Aldobiouronic Acid Isolated from the Unicellular Red Alga Rhodella Reticulata."

Jaseja, M.; Perlin, A. S.; Dubinsky, O.; Christiaen, D.; Arad, S.; Glaser, R. Carbohydr. Res. 1989, 186, 313.

47. "Stereoisomer Differentiation for the Analgesic Drug Nefopam Hydrochloride via Modeling Studies of the Serotonin Uptake Area."

Glaser, R.; Donnell, D. J. Pharm. Sci. 1989, 78, 87.

48. "1H and 13C NMR Studies on the Oxydimethyleneaminomethyl Fragment in Six- and Eight-Membered Rings. The Solution Stereochemistry of N-Methyl Diastereomers of Phendimetrazine (an Oxazine Anorexic Drug) versus Nefopam (a Benzoxazocine Analgesic Drug)."

Glaser, R. Magn. Reson. Chem. 1989, 27, 1142.

49. "The Preparation and NMR Characterization of a Hydrido-bridged Gold−Iridium Binuclear Complex Containing the Chelating Tritertiary Phosphine Cyttp Ligand."

Socol, S. M.; Meek, D. W.; Glaser, R. Polyhedron 1989, 8, 1903.

50. "Solid State Stereochemistry of Anhydrous (–)-Scopolamine Hydrobromide."

Glaser, R.; Charland, J. -P.; Michel, A. J. Chem. Soc., Perkin Trans. 2 1989, 1875.

51. "Preparation, 1H- and 13C-NMR Structure Determination, and Fungicidal Activity of Chlorinated 1-Arylamino-1H-Pyrrole-5-Diones."

Yaroslavsky, C.; Bracha, P.; Glaser, R. J. Heterocylc. Chem. 1989, 26, 1649.

52. "Cannabimimetic Activity of Novel Enantiomeric, Benzofuran Cannabinoids."

Mechoulam, R.; Breuer, A.; Järbe, T. U. C.; Hiltunen, A. J.; Glaser, R. J. Med. Chem. 1990, 33, 1037.

53. "CP-MAS 13C-NMR Spectroscopy and X-ray Crystallography Studies on the Solid-State Stereochemistry of Diphenhydramine Hydrochloride, an Antihistaminic Drug."

Glaser, R.; Maartmann-Moe, K. J. Chem. Soc., Perkin Trans. 2 1990, 1205.

54. "1H and 13C NMR Conformational Studies on Quaternary Nitrogen Derivatives of Nefopam, an Analgesic Drug."

Glaser, R.; Peleg, A.; Geresh, S. Magn. Reson. Chem. 1990, 28, 389.

55. "The Two Solid-State Conformations of Nefopam Methiodide, a Quaternary Ammonium Salt of the Analgesic Drug." Invited contribution to A. S. Perlin Special Issue.

Glaser, R.; Michel, A.; Drouin, M. Can. J. Chem. 1990, 68, 1128.

56. "Structure of 3-O-(α-D-glucopyranosyluronic acid)-L-galactopyranose, an aldobiouronic acid isolated from the polysaccharides of various unicellular red algae."

Geresh, S.; Dubinsky, O.; Arad, S.; Christiaen, D.; Glaser, R. Carbohydr. Res. 1990, 208, 301.

57. "Oxidation of Cu(II) Bis(glycinate) by Methyl Free Radicals in Aqueous Solutions. A Pulse Radiolysis Study."

Masarwa, M.; Cohen, H.; Glaser, R.; Meyerstein, D. Inorg. Chem. 1990, 29, 5031.

58. "Structure of some Sulfated Sugars Isolated after Acid Hydrolysis of the Extracellular Polysaccharide of Porphyridium sp., a Unicellular Red Alga."

Lupescu, N.; Arad, S.; Geresh, S.; Bernstein, M. A.; Glaser, R. Carbohydr. Res. 1991, 210, 349.

59. "Effects of Pyrroloisoquinoline Enantiomers ((+)- and (–)-McN-5652-Z) on Behavioral and Pharmacological Serotonergic Mechanisms in Rats."

Smith, D. F.; Jensen, P N.; Poulsen, S. H.; Mikkelsen, E. O.; Elbaz, E.; Glaser, R. Eur. J. Pharmacol. 1991, 196, 85.

60. "1H and 13C NMR Studies on the Conformation of E,Z- Diastereomers of N-Desmethyl-N,O- Diacetyl α-Metazocine (sp2-Hybridized Nitrogen Derivatives of a Benzomorphan Narcotic Analgesic)."

Glaser, R.; Bernstein, M.A.; Balan, A. Magn. Reson. Chem. 1991, 29, 766.

61. "Helical Stereochemistry and Chiral Apple Halves."

Glaser, R. Struc. Chem. 1991, 2, 479.

62. "The Unsymmetrical Silaketal as a Neutral, Removable Tether for Effecting Intramolecular Diels-Alder Reactions."

Gillard, J. W.; Fortin, R.; Grimm, E. L.; Maillard, M.; Tjepkema, M.; Bernstein, M.; Glaser, R. Tetrahedron Lett. 1991, 32, 1145.

63. "1H and 13C NMR Studies on the Conformation of N-methyl Diastereomers of (+)-Glaucine Hydrotrifluoroacetate, an Aporphine Alkaloid Salt."

Glaser, R.; Bernstein, M. A. J. Chem. Soc., Perkin Trans. 2 1991, 2047.

64. "Separation and Characterization of the Stereoisomeric Reaction Products of (±)-Epichlorohydrin with Di(4-aminophenyl) Ether."

Glaser, R.; Bar-Yaakov, Y.; Shmueli, Y. New J. Chem. 1992, 16, 747.

65. "The Solid-State Structure of Orphenadrine HCl (Antiparkinson) and Conformational Comparisons with Diphenhydramine HCl (Antihistaminic) and Nefopam HCl (Non-narcotic Analgesic)."

Glaser, R.; Donnell, D.; Maartmann-Moe, K. J. Pharm. Sci. 1992, 82, 858.

66. "Spectroscopic and Reactivity Studies of Diastereomeric Iridium(III) Hydride Complexes of the Chelating Tritertiary Phosphine Ligand Cyttp."

Socol, S. M.; Yang, C.; Meek, D. W.; Glaser, R.; Can. J. Chem. 1992, 70, 2424.

67. "Solution- and Solid-State Stereochemistry of (–)-α-Lobeline Hydrobromide and Hydrochloride, a Respiratory-Stimulant Drug."

Glaser, R.; Hug, P.; Drouin, M.; Michel, A. J. Chem. Soc., Perkin Trans. 2 1992, 1071.

68. "The Solution-State Conformation of (–)-Scopolamine Free Base."

Glaser, R. Magn. Reson. Chem. 1993, 31, 335.

69. "The Solution- and Solid-State Structure of N-Desmethylnefopam Hydrochloride, a metabolite of the Analgesic Drug."

Glaser, R.; Geresh, S.; Blumenfeld, J.; Donnell, D.; Sugisaka, N.; Drouin, M.; Michel, A. J. Pharm. Sci. 1993, 82, 276.

70. "Helical Stereochemistry and Chiral Apple Halves. 2. La Coupe du Roi via Double Helical Complexation using Oligo(bipyridine) Strands and Cu(I)/Ag(I)."

Glaser, R. Chirality 1993, 5, 272.

71. "Enzymatic Separation of Cis-/Trans-Mixtures of 1,4-Cyclohexanedimethanol by Mono- and Polytransesterification."

Geresh, S.; Elbaz, E.; Glaser, R. Tetrahedron 1993, 49, 4939.

72. "Solid-State Stereochemistry of 3-Methylnefopam Diastereomers. Manipulation of Eight- membered Ring Conformations in Analogues of the Non-narcotic Analgesic Drug."

Glaser, R.; Blumenfeld, J.; Geresh, S.; Donnnell, D.; Rosland, J. H.; Hole, K.; Maartmann-Moe, K. J. Pharm. Sci. 1993, 82, 886.

73. "Electronic Substituent Effects in the Nitrilase-Catalyzed Hydrolysis of Substituted Benzyl Cyanides."

Geresh, S.; Giron, Y.; Gilboa, Y.; Glaser, R. Tetrahedron 1993, 49, 10099.

74. "NMR Studies on the Solution-State Stereochemistry of 3-Methylnefopam Hydrochloride Diastereomers. Conformational and N-Configurational Interconversion in Analogues of the Non-narcotic Analgesic Drug."

Glaser, R.; Blumenfeld, J.; Geresh, S. Magn. Reson. Chem. 1993, 31, 845.

75. "Solid-State Stereochemistry of (–)-Scopolamine Hydrobromide Sesquihydrate, a New Polymorph of the Anticholinergic Drug."

Michel, A.; Drouin, M.; Glaser, R. J. Pharm. Sci. 1994, 83, 508.

76. "Solid State Structure of (+)-Phendimetrazine Bitartarate, an Anorexic Drug."

Glaser, R.; Adin, I.; Drouin, M.; Michel, A. Struct. Chem. 1994, 5, 197.

77. "The Solid-State Structure of (+)-(l)-Menthyl 2-Formamido-4,4,4-trifluorobutanoate and the Hydrogenation of the 2-Butenoate Precursor."

Glaser, R.; Geresh, S.; Luria, S.; Drouin, M.; Michel, A. Struct. Chem. 1994, 5, 277.

78. "Eight-Membered Ring Conformations. The Interconversion of the Solid-State Conformations of Retronefopam Hydrochloride and Deoxynefopam Hydrochloride into those Exhibited by Nefopam Hydrochloride, a Non-Narcotic Analgesic Drug."

Glaser, R.; Shiftan, D.; Drouin, M. New J. Chem. 1994, 18, 973.

79. "2-Methyl and 4-Methyl-Δ8-Tetrahydrocannabinol: Correlation of Spatial Distinction with Cannabinoid Receptor Binding."

Glaser, R.; Adin, I.; Mechoulam, R.; Hanus, L. Heterocycles 1995, 39, 867.

80. "The Stereochemistry of a Nine-membered Ring Analogue of Nefopam, a Non-Narcotic Analgesic Drug."

Glaser, R.; Shiftan, D.; Drouin, M. Struct. Chem. 1995, 6, 25.

81. "Solid-State Structure Determination and Solution-State NMR Characterization of the (2R,4R)/(2S,4S)- and (2R,4S)/(2S,4R)-Diastereomers of the Agricultural Fungicide Propiconazole, the (2R,4S)/(2S,4R)-Symmetrical Triazole Constitutional Isomer, and a Ditriazole Analogue."

Glaser, R.; Adin, I.; Ovadia, D.; Mendler, E.; Drouin, M. Struct. Chem. 1995, 6, 145.

82. "Solution-State Conformational Homogeneity in Eight-Membered Rings Containing Vicinal Lone-Pairs of Electrons."

Glaser, R.; Adin, I.; Drouin, M.; Bremner, J. B. New J. Chem. 1995, 19, 1099.

83. "M. C. Escher's Drawings as an Educational Tool for General and Special Positions of Symmetry in Crystals and Molecules."

Glaser, R. Enantiomer 1996, 1, 233.

84. "An 1H NMR Study of Conformational Differences in 3-Tert.-butyldimethylsiloxy- and 9-Methyl-8-oxa-9-azabicyclo[3.2.2]non-6-en-3-ol Intermediates for Bridgehead Hydroxylated Tropane Alkaloid Derivatives."

Glaser, R.; Tarrant, G. J.; Bremner, J. B. Magn. Reson. Chem. 1997, 35, 389.

85. "Further Evidence for a Pharmacophore for Dopamine Reuptake Blockers. The Effect of N-Methylation on Methylphenidate and Its Analogs."

Froimowitz, M.; Deutsch, H. M.; Shi, Q.; Wu, K.-M.; Glaser, R.; Adin, I.; George, C.; Schweri, M. M. Bioorg. Med. Chem. Lett. 1997, 7, 1213.

86. "Scopolamine and Atropine N-methyl Diastereomer Stability. Ab-initio Calculations on O-Formylscopine and O-Formyltropine Model Compounds."

Glaser, R.; Khutorsky, V.; Shokhen, M. Struct. Chem. 1997, 8, 319.

87. "Distribution of Electrostatic Fields around Biological Molecules studied by Spin-Probe Methods."

Likhtenshtein, G. I.; Adin, I.; Krasnoselsky, A.; Vaisbuch, I.; Shames, A.; Glaser, R. Biophys. J. 1997, 77, A129.

88. "Solution and Solid-State Conformational and Structural Analysis of the N-Methyl Derivatives of (±)-Threo-Methylphenidate, (±)-Erythro-Methylphenidate and (±)-Threo-p-methyl-methylphenidate HCl Salts."

Glaser, R.; Adin, I.; Shiftan, D.; Shi, Q.; Deutsch, H. M.; George, C.; Wu, K.-M.; Froimowitz, M. J. Org. Chem. 1998, 63, 1785.

89. "I-symmetry, the Highest Chiral Point Group, and the Icosahedral Structure of Virus Particles."

Glaser, R. Enant. 1998, 2, 479.

90. "The Stereochemistry and Interconversion of Nine-membered Rings Containing One Strong Torsional Constraint."

Glaser, R.; Shiftan, D. Advances Molec. Struct. Res. 1999, 5, 89-151.

91. "NMR and ESR Studies of Electrostatic Field Distribution Around Biologically Important Molecules."

Likhtenshtein, G. I.; Adin, I.; Novoselsky, A.; Shames, A.; Vaisbuch, I.; Glaser, R. Biophys. J. 1999, 77, 443.

92. "Conformational Pseudopolymorphism and Solid-State CPMAS NMR Studies for Determination of Solvent-Dependent Solution-State Conformational Preferences for (–)-Scopolamine Hydrobromide/Hydrochloride Salts."

Glaser, R.; Shiftan, D.; Drouin, M. J. Org. Chem. 1999, 64, 9217.

Additions and Corrections: ibid. 2000, 65, 1898.

93. "NMR Structure Determination of Brefeldin-A, a 13-Membered Ring Fungal Metabolite."

Glaser, R.; Shiftan, D., Froimowitz, M. Magn. Reson. Chem. 2000, 38, 274.

94. "The Solid-State Structures of (–)-Scopolamine Free Base, (–)-Scopolamine Methobromide, (–)-Scopolamine Hydrobromide Trihydrate, and of the Pseudopolymorphic Forms of (–)-Scopolamine Hydrochloride Anhydrate and 1.66Hydrate."

Glaser, R.; Shiftan, D.; Drouin, M. Can. J. Chem. 2000, 78, 212.

95. "Eight-Membered Ring Solid-State Conformational Interconversion via the Atom-Flip Mechanism, a CPMAS 13C NMR and Crystallographic Stereochemical Study."

Glaser, R.; Novoselsky, A.; Shiftan, D.; Drouin, M. J. Org. Chem. 2000, 65, 6345-6353.

96. "NMR Studies of Electrostatic Fields Around Charged Monosaccharides and Related Molecules."

Glaser, R.; Novoselsky, A.; Shames, A.; Likhtenshtein, G. I. Isr. J. Chem. special Lemieux issue 2000, 40, 263-269.

97. "A General View of Symmetry Considerations in NMR Spectroscopy."

Glaser, R. In Symmetry 2000, Hargittai, I., Torvard, L., Eds.; Portland Press: London, 2001; pp 371-383. invited paper

98."Effect of Ionic Strength on the Binding of Ascorbate to Albumin"

Lozinsky, E.; Novoselsky, A.; Glaser, R.; Shames, A. I.; Likhtenshtein, G. I.; Meyerstein, D.

Biophys. Biochim. Acta 2002, 1571, 239-244.

99. "Magnetic resonance studies on ascorbate binding to albumin."

Lozinsky, E.; Novoselsky, A.; Shames, A. I.; Glaser, R.; Likhtenshtein, G. I.; Meyerstein, D.

In EPR in the 21st Century: Basics and Applications to Material, Life and Earth Sciences, Kawamori, A., Yamauchi, J., Ohta, H., Eds.; Elsevier: Amsterdam, 2002; pp 471-476.

100. "Cis-Cyclononene Conformational Families, and a Crystallographic Example of a Skew-Boat-Chair Type-2 Conformation."

Glaser, R.; Shiftan, D.; Levi-Roso, G.; Ergaz, I.; Geresh, S. J. Org. Chem. 2002, 67, 5486-5496.

101. "Solid-state CP/MAS 13C NMR Studies on Conformational Polymorphism in Sertraline Hydrochloride, an Antidepressant Drug"

Novoselsky, A.; Glaser, R. Magn. Reson. Chem 2002, 40, 723-728.

102."Molecular Dynamics Investigation of an Antibody Binding Site by the Fluorescence-Photochrome Method."

Chen, O.; Glaser, R.; Likhtenshtein, G. I. Biophys. Chem. 2003, 103, 139-156.

103. "The Solid-State and Solution-State Structures of Tagitinin A, a 3,10-Epoxy-Germacrolide Natural Product, and the Interconversion of 3,10-Epoxy-Germacrolide Conformational Families via a Ring-Atom Flip Mechanism."

Glaser, R.; García, E. A.; Chávez, M. I.; Delgado, G. Brasilian J. Chem. 2005, 16, 440-448.

104. "Solution- and Solid-State NMR Studies of Eight- and Nine-Membered Medium Ring Cis-Cycloalkene Stereochemistry."

Glaser, R.; Ergaz, I.; Levi-Ruso, G.; Shiftan, D.; Novoselsky, A.; Geresh, S. Royal Chemical Society Ann. Rep. NMR Spec. 2005, 56, 145-213.

105. "The Novel FluoroChrome ImmunoAssay – (FCIA). The Role of Molecular Environment upon Molecular Structure Exemplified by Constriction of a Flourescence-Photochrome Flanked by Two Proteins." Chen, O.; Glaser, R.; Likhtenshtein, G. I. J. Biochem. Biophys. Methods submitted.

106. "Chiral Recognition via Helical Sense and Phase in a Crystalline Supramolecular Array of Intermeshed Triple-Helices."

Glaser, R. submitted.

107. "The Effect of Environment on Molecular Structure: the Crystalline-State Stereochemistry of N-Methylated Adamantane-1,3-Diammonium Salts."

Ergaz, I.; Toscano, R. A.; Delgado, G.; Steinberg, A.; Glaser, R. Submitted

108. "Generic Drugs and Crystalline Polymorphism."

Glaser, R. Submitted.