Contacts

Ronald Sluyter

Associate Professor Ronald Sluyter

PhD University of Sydney (1999)
BAppSc (Hons) (First class) University of Technology, Sydney (1991)

Email:       rsluyter@uow.edu.au
Phone:     +61 2 4221 5508
Office:      B32.309

Positions

 Research Interests
  • Human and veterinary medicine
  • The P2X7 receptor
  • Purinergic signalling
  • Immunology
  • Neurobiology
  • Haematology
  • Cancer biology

Recent Publications

James LRA, Sluyter R, Dillon CT, Ralph SF. Effects of gold nanoparticles and gold anti-arthritic compounds on inflammation marker expression in macrophages. Australian Journal of Chemistry, in press, 2017.

Geraghty NJ, Mansfield KJ, Fuller SJ, Watson D*, Sluyter R*. The P2X7 receptor is not essential for development of imiquimod-induced psoriasis-like inflammation in mice. Purinergic Signalling, in press, 2017, *equal senior authors.

Bartlett R, Sluyter V, Watson D, Sluyter R* Yerbury JJ*. The P2X7 antagonist Brilliant Blue G reduces body weight loss and prolongs survival in female SOD1G93A amyotrophic lateral sclerosis mice. PeerJ, 5: e3064, 2017, *equal senior authors

Yuan D, Tan SH, Zhao Q, Yan S, Sluyter R, Nguyen NT, Zhang J, Li W. Sheathless Dean-flow-coupled elasto-inertial particle focusing and separation in viscoelastic fluid. RSC Advances, 7: 3461-3469, 2017

Faulks M, Kuit TA, Sophocleous RA, Curtis BL, Curtis SJ, Jurak LM, Sluyter R. P2X7 receptor activation causes phosphatidylserine exposure in canine erythrocytes. World Journal of Hematology, 5: 88-93, 2016

Yuan D, Zhang J, Sluyter R, Zhao Q, Yan S, Alici G, Li W. Continuous plasma extraction under viscoelastic fluid in a straight channel with asymmetrical expansion-contraction cavity arrays. Lab on a Chip, 16: 3919-3928, 2016

Pupovac A, Sluyter R. Roles of extracellular nucleotides and P2 receptors in ectodomain shedding. Cellular and Molecular Life Sciences, 73: 4159-4173, 2016

Sluyter R, Vine KL. N-Alkyl-substituted isatins enhance P2X7 receptor-induced interleukin-1β release from murine macrophages. Mediators of Inflammation, 2016: 2097219, 2016

Geraghty NJ, Watson D, Adhikary SR, Sluyter R. The P2X7 receptor in skin biology and diseases. World Journal of Dermatology, 5: 72-83, 2016

Stokes L, MacKenzie AB, Sluyter R. Editorial: Roles of ion channels in immune cells. Frontiers in Immunology, 7: 48, 2016

Sluyter R. P2X and P2Y receptor signaling in red blood cells. Frontiers in Molecular Biosciences, 2: 60, 2015

Sophocleous RA, Mullany PRF, Winter KM, Marks DC, Sluyter R. Propensity of red blood cells to undergo P2X7 receptor-mediated phosphatidylserine exposure does not alter during in vivo or ex vivo aging. Transfusion, 55: 1946-1954, 2015

James LRA, Xu ZQ, Sluyter R, Hawksworth EL, Kelso C, Lai B, Paterson DJ, de Jonge MD, Dixon NE, Beck JL, Ralph SF, Dillon CT. An investigation into the interactions of gold nanoparticles and anti-arthritic drugs with macrophages, and their reactivity towards thioredoxin reductase. Journal of Inorganic Biochemistry, 142: 28-38, 2015

Pupovac A, Geraghty NJ, Watson D, Sluyter R. Activation of the P2X7 receptor induces the rapid shedding of CD23 from human and murine B cells.Immunology and Cell Biology, 93: 77-85, 2015

Sluyter R, Stokes L. Polymorphic variants of the P2X7 receptor in the domestic dog. Jacobs Journal of Veterinary Science and Research, 1: 8, 2015.

Sluyter R, Watson D. T cells continue to play on the ATP circuit. Journal of Immune Research, 1: 2, 2014

Bartlett R, Stokes L, Sluyter R. The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease. Pharmacological Reviews, 66: 638-675, 2014

Yan S, Zhang J, Li M, Alici G, Du H, Sluyter R, Li W. On-chip high-throughput manipulation of particles in a dielectrophoresis-active hydrophoretic focuser, Scientific Reports, 4: 5060, 2014

Spildrejorde M, Bartlett R, Stokes L, Jalilian I, Peranec M, Sluyter V, Curtis BL, Skarratt KK, Skora A, Bakhsh T, Seavers A, McArthur JD, Dowton M, Sluyter R. R270C polymorphism leads to loss of function of the canine P2X7 receptor. Physiological Genomics, 46: 512-522, 2014

Zhang J, Yan S, Sluyter R, Li W, Alici G, Nguyen N.T. Inertial particle separation by differential equilibrium positions in a symmetrical serpentine micro-channel, Scientific Reports, 4: 4527, 2014

Bhaskaracharya A, Dao-Ung P, Jalilian J, Spildrejorde M, Skarratt KK, Fuller SJ, Sluyter R, Stokes L. Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism. PLoS ONE, 9: e93058, 2014

Sluyter R, Wiley JS. P2X7 receptor activation induces CD62L shedding from human CD4+ and CD8+ T cells. Inflammation and Cell Signaling, 1: e92, 2014

Spildrejorde M, Curtis SJ, Curtis BL, Sluyter R. Extracellular adenosine 5’-triphosphate and lipopolysaccharide interleukin-1β release in canine blood. Veterinary Immunology and Immunopathology, 157: 105-110, 2014

Pupovac A, Stokes L, Sluyter R. CAY10593 inhibits the human P2X7 receptor independently of phospholipase D1 stimulation. Purinergic Signalling, 9: 609-619, 2013 

Pupovac A, Foster CM, Sluyter R. Human P2X7 receptor activation induces the rapid shedding of CXCL16. Biochemical and Biophysical Research Communications. 432: 626-631, 2013

Bartlett R, Yerbury JJ, Sluyter R. P2X7 receptor activation induces reactive oxygen species formation and cell death in murine EOC13 microglia. Mediators of Inflammation. 2013: 271813, 2013

Wang B, Sluyter R. P2X7 receptor activation induces reactive oxygen species formation in erythroid cells. Purinergic Signalling. 9: 101-112, 2013

Jalilian I, Spildrejorde M, Seavers A, Curtis BL, McArthur JD, Sluyter R. Functional expression of the damage-associated molecular pattern receptor P2X7 on canine kidney epithelial cells. Veterinary Immunology and Immunopathology. 150: 228-233, 2012

Gadeock S, Pupovac A, Sluyter V, Spildrejorde M, Sluyter R. P2X7 receptor activation mediates organic cation uptake into human myeloid leukaemic KG-1 cells. Purinergic Signalling. 8: 669-676, 2012

Jalilian I, Peranec P, Curtis BL, Seavers A, Spildrejorde M, Sluyter V, Sluyter R. Activation of the damage-associated molecular pattern receptor P2X7 induces interleukin-1β release from canine monocytes. Veterinary Immunology and Immunopathology. 149: 86-91, 2012



Current Staff
  • Dr Diane Ly, PhD, BMedBiotechAdv (Hons), Research Fellow
     
Current Students

PhD

  • Reece Sophocleous, 2016-, Project title: Structure and function of P2 receptors
  • Sam Adhikary, 2016-, Project title: Therapeutic strategies to prevent graft-versus-host disease
  • Nicholas Geraghty, 2015-, Project title: The P2X7 receptor in inflammatory disorders

MRes

  • Anjila Dongol, 2017-, Project title: The P2X7 receptor in amyotrophic lateral sclerosis

Honours

  • Peter Cuthbertson, 2017, Project title: Gastrointestinal and cutaneous graft-versus-host disease
Past UOW Students
  • PhD: Rachael Bartlett 2012-2016, Lloyd James 2011-2016 Aleta Pupovac 2010-14
  • MSc (Research): Mari Spildrejorde 2011-12, Iman Jalilian 2010-11, Bin Wang 2010-11, Safina Gadeock 2009-10
  • BSc (Hons): Lachlan Bell 2015, Lisa Jurak 2015, Phillip Mullany 2013-14, Reece Sophocleous 2013, Michelle Peranec 2011, Chris Thekkadam 2011 (external), Patrick Constantinescu 2008, Andrew Farrell 2008
  • BMedBiotech (Hons): Sam Adhikary 2015, Megan Faulks 2015, Shikara Keshiya 2015, Nicholas Geraghty 2014, Lisa Belfiore 2013, Rachael Bartlett 2011, Aleta Pupovac 2009
  • BMedHlthSc (Hons): Belinda Kaleska 2015
  • Major Research Project (BIOL991): Bin Wang 2009
  • Research Project (BIOL993): Tahani Bakhsh 2011, Mari Spildrejorde 2011
  • Literature Review Project (BIOL992): Sahar Alkaff 2011
  • Advanced Biology (BIOL392): Luke Hilliar 2013, Rachael Bartlett 2010, Chris Thekkedam, 2009, Aleta Pupovac, 2008
  • Research Internship (SCIE392): Shannah Gates 2015, Christopher Foster 2010, Kati Kovacevic 2009 
  • Faculty Research Assistants: Emma-Jayne Proctor 2014, Le May Thai 2013

Suggested Topics for Future Students

Our group has a number of projects available investigating the role of purinergic receptors in inflammatory, cutaneous, haematological and neurological disorders.


Abbreviated CV

Employment History

  • Associate Professor, University of Wollongong, 2015-
  • Senior Lecturer, University of Wollongong, 2008-2014
  • Senior Research Fellow, Nepean Clinical School, University of Sydney, 2003-2007
  • Research Fellow, Nepean Clinical School, University of Sydney, 2000-2003
  • Research Fellow, Department of Pathology, University of Sydney, 1999
  • Research Assistant, Department of Medicine, University of Sydney, 1992-1994

Academic Degrees

  • PhD, The University of Sydney, 1999
  • BAppSc (Hons) (First class), The University of Technology, Sydney, 1991  

External Grants

  • Motor Neurone Disease Research Institute of Australia, Grant-in-aid, Establishing the therapeutic potential of the P2X7 receptor ion channel in amyotrophic lateral sclerosis, 2017
  • Australian Companion Animal Health Foundation, Project Grant, Molecular mechanisms in coagulation and thrombotic events in dogs and cats, 2016-2017
  • American Kennel Club Canine Health Foundation, Project Grant, Role of P2X receptors in chronic pain, 2014-2015
  • Australian Companion Animal Health Foundation, Project Grant, Genetic variants of the damage-associated molecular pattern receptor P2X7 in dogs: potential role in inflammatory and bone disorders, and pain, 2012
  • Canine Research Foundation, Project Grant, NALP3 inflammasome activation in canine heath and disease, 2011
  • American Kennel Club Canine Health Foundation, Project Grant, Understanding mechanisms involved in canine autoimmune and inflammatory disorders, 2010-2011
  • Cure Cancer Australia Foundation, Project Grant, The P2X7 receptor and microparticles in cancer-associated thromboembolism, 2008
  • NHMRC, Project Grant, Role of P2X7 in innate and adaptive immunity to mycobacterial infections, 2005-2007
  • The Clive and Vera Ramaciotti Foundation and the Nepean Medical Research Foundation, Equipment Grants, FLUOstar OPTIMA fluorescent microplate reader, 2006
  • NHMRC, Project Grant, Tumour B-cells from lymphomas are resistant to ATP-mediated apoptosis due to non-functional P2X7 receptors, 2002-2004
  • Leo & Jenny Leukaemia and Cancer Foundation, Project Grant, Role of ecto-apyrases in the loss of P2X7 receptor function in malignant lymphoma, 2001

Awards and Scholarships

  • European Travel Award, Australian Academy of Sciences, 2007
  • Isobel Corin Research Travel Award, Nepean Medical Research Foundation, 2006
  • Nepean Medal, University of Sydney, 2004
  • Conference Bursary Award, Australasian Society for Immunology, 1996
  • Postgraduate Travel Award, Univeristy of Sydney, 1994
  • Australian Postgraduate Award (with Stipend), Univeristy of Sydney, 1994
  • HECS Exemption Research Award, Univeristy of Technology, Sydney, 1991

Professional Affiliations and Associations

Last reviewed: 28 August, 2018