Neuroscience & Degenerative Diseases

Neuroscience And Degenerative Diseases

Due to increasing life expectancies, age–related neurodegenerative diseases like Alzheimer’s have become a major health burden. CMMB researchers are focussing on the molecular mechanisms that lead to neurodegenerative disease with a view to developing therapeutic strategies. In a related area, a major new grouping of our researchers focuses on how chaperone proteins, including those in human blood, protect other proteins from being misfolded during development of a variety of “protein folding” disorders like motor neuron disease, Alzheimer’s disease and Parkinson’s disease.

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CURRENT AND RECENT PROJECTS

Project Title: Isoform-dependent apoE processing by human induced pluripotent stem cells. A novel pathway linking APOE genotype and Alzheimer's disease risk
2015 NHMRC Project Grant
CMMB Investigators: Professor Brett Garner, Dr Lezanne Ooi, Dr Hongyun Li

Project Title: Protein homeostasis, protein aggregation and Amyotrophic Lateral Sclerosis
2015 NHMRC Career Development Fellowship
CMMB Investigator: Dr Justin Yerbury

Project Title: Lysosomal dysfunction as an inhibitor of vitamin B12 utilisation in neurodegenerative diseases
2014 NHMRC Project Grant
CMMB Investigators: Professor Brett Garner, Dr Andrew Jenner, Dr Hua Zhao

Project Title: Application of intelligent conducting polymers for treating schizophrenia and allied disorders focusing on neuronal outgrowth, myelination and synaptogenesis
2014 NHMRC Project Grant
CMMB Investigators: Professor Xu-Feng Huang

Project Title: Supporting a friend: the role of the molecular scaffold CoREST family in chromatin regulation and neuroprotection
2014 NHMRC Project Grant
CMMB Investigators: Dr Lezanne Ooi, Professor Brett Garner

Project Title: Understanding age-related protein aggregation. The mechanism of cataract and its prevention
2014 NHMRC Project Grant
CMMB Investigator: Professor Roger Truscott

Project Title: Roles of muscarinic M3 receptors in antipsychotic-induced metabolic side-effects: prevention and treatment of anti-psychotic insulin dysregulation
2013 NHMRC Project Grant
CMMB Investigators: Associate Professor Chao Deng, Professor Xu-Feng Huang

Project Title: A novel intracellular roadblock to cobalamin utilization in ageing and Alzheimer's disease
2013 NHMRC Project Grant
CMMB Investigators: Professor Brett Garner, Dr Andrew Jenner

Project Title: Are proteostasis defects responsible for Amyotrophic Laterial Sclerosis?
2012 ARC Discovery Early Career Researcher Award (DECRA)
CMMB Investigator: Dr Justin Yerbury

Project Title: Schizophrenia: reversal of antipsychotic drug-induced obesity and its related metabolic disorders
2012 NHMRC Project Grant
CMMB Investigators: Professor Xu-Feng Huang, Associate Professor Chao Deng, Dr Francesca Fernandez

Project Title: Targeting small heat shock proteins in diseases associated with alpha-synuclein aggregation
2012 NHMRC Project Grant
CMMB Investigator: Associate Professor Heath Ecroyd

Project Title: Altered myelin sphingolipid homeostasis in Alzheimer's Disease
2012 NHMRC Project Grant
CMMB Investigator: Professor Brett Garner

Project Title: Small heat shock proteins: front-line defenders and therapeutic targets
2011 ARC Future Fellowship
CMMB Investigator: Associate Professor Heath Ecroyd

Project Title: Understanding the mechanisms of functionally selective drugs: implication for new generation antipsychotic drugs
2011 NHMRC Project Grant
CMMB Investigator: Associate Professor Chao Deng

Project Title: Vulnerability markers in the association between cannabis and schizophrenia
2011 NHMRC Project Grant
CMMB Investigator: Dr Francesca Fernandez

Project Title: Investigating the propagation of protein aggregation in amyotrophic lateral sclerosis
2011 NHMRC Project Grant
CMMB Investigator: Dr Justin Yerbury

Project Title: Defining the function of apolipoprotein-D in Alzheimer's disease
2011 NHMRC Project Grant
CMMB Investigator: Professor Brett Garner

Project Title: Ancient proteins and disease
2011 NHMRC Project Grant
CMMB Investigators: Associate Professor Todd Mitchell, Professor Roger Truscott 

Project Title: The role of clusterin in preventing atherosclerosis
2011 NHMRC Training Fellowship
CMMB Investigator: Dr Amy Watt

Project Title: Cellular effects of glucocerebrosidase (GBA) mutations in Lewy body diseases
2011 NHMRC Project Grant
CMMB Investigator: Professor Brett Garner

Project Title: Schizophrenia: prevention and treatment of atypical antipsychotic drug-induced obesity
2010 NHMRC Project Grant
CMMB Investigators: Professor Xu-Feng Huang, Associate Professor Chao Deng
 

Last reviewed: 24 August, 2017