Infectious Diseases & Anti-Microbial Agents

Infectious Diseases And Anti-microbial Agents

Development of resistance to current drugs by pathogenic micro-organisms is of very serious concern. CMMB researchers are tackling this problem by several complementary approaches. For example, small molecule compounds that interfere with essential processes in bacteria are being discovered that have potential for development into a new generation of antibiotics. Studies of fundamental mechanisms of bacterial survival and pathogenesis provide information on which to base this work. 


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CURRENT AND RECENT PROJECTS

Project Title: Functional dissection of the bacterial replisome
2015 ARC Discovery Project
CMMB Investigators: Professor Antoine van Oijen, Professor Nicholas Dixon

Project Title: Mechanisms of immune-evasion by Group A Streptococcus during skin infection
2015 NHMRC Project Grant
CMMB Investigator: Dr Martina Sanderson-Smith

Project Title: Under the hood: single-molecule studies of multi-protein machines
2014 Australian Laureate Fellowship
CMMB Investigator: Professor Antoine van Oijen

Project Title: New strategies for the stereoselective synthesis of stemona alkaloids and the Discovery of new bioactive molecules
2013 ARC Discovery Project
CMMB Investigator: Professor Stephen Pyne 

Project Title: The development of novel antibacterials targeting Clostridium Difficile Infections
2013 NHMRC Project Grant
CMMB Investigators: Professor Stephen Pyne, Professor Paul Keller

Project Title: Targeting Nucleic Acid Synthesis and Cell Division in Gram-Negative Bacterial Pathogens
2012 NHMRC Project Grant
CMMB Investigators: Professor Nicholas Dixon, Associate Professor Aaron Oakley, Professor Jennifer Beck

Project Title:  A Polyvalent Group A Streptococcal Vaccine: Evaluation of a vaccine to combat common streptoccoal diseases
2012 NHMRC Project Grant
CMMB Investigator: Dr Martina Sanderson-Smith

Project Title: Fragment-Based Screening Approaches for New Antibiotics Directed Against the Bacterial Sliding Clamp
2011 ARC Discovery Project
CMMB Investigators: Associate Professor Aaron Oakley, Professor Jennifer Beck, Associate Professor Michael Kelso

Project Title: Defining the role of plasminogen activation in group A streptococcal invasive disease
2011 NHMRC Career Development Award
CMMB Investigator: Dr Martina Sanderson-Smith

Project Title: Targeting lagging strand DNA replication in model and pathogenic bacteria
2011 NHMRC Project Grant
CMMB Investigators: Professor Nicholas Dixon, Associate Professor Aaron Oakley

Project Title: Stereoselective synthesis of bioactive alkaloids for structure elucidation and drug discovery
2010 ARC Discovery Project
CMMB Investigator: Professor Stephen Pyne

Project Title: Role of the host fibrinolytic system in invasive group A streptococcal disease
2010 NHMRC Project Grant
CMMB Investigator: Dr Martina Sanderson-Smith
 

 

Last reviewed: 7 March, 2016