Contacts

Kelso scaled 260 300

A/Prof Michael J Kelso  

B.Med. Chem. (Hons 1), University of Wollongong, 1996 (University Medal for the Faculty of Science)
Ph.D., Institute for Molecular Bioscience, University of Queensland, 2002 (with Professor David Fairlie) 

Email:        mkelso@uow.edu.au
Phone:     +61 2 4221 5085
Office:       B18.115

Position     
  • Associate Professor

Research Interests

Medicinal chemistry, drug design and synthesis, structure-based drug design, prodrug design and synthesis, anti-tumour agents, anti-microbial agents, DNA binding anthracyclines, biofilm dispersing agents, catalytic asymmetric synthesis.


ReCENT Publications
  • 7Synthesis of Cephalosporin-3′-Diazeniumdiolates: Biofilm Dispersing NO-Donor Prodrugs Activated by b-Lactamase. Yepuri, N. R.; Barraud, N.; Mohammadi, N. S.; Kardak, B. G.; Kjelleberg, S.; Rice, S. A.; Kelso, M. J. Chem. Commun. 2013, 49, 4791-4793.
  • Cephalosporin-3′-Diazeniumdiolates: Targeted NO-Donor Prodrugs for Dispersing Bacterial Biofilms. Barraud, N.; Kardak, B. G.; Yepuri, N.R.; Howlin, R.P.; Webb, J. S; Faust, S.   N.; Kjelleberg, S.; Rice, S. A.; Kelso, M. J. Angew. Chem. Int. Ed. 2012, 51, 9057-9060.
  • Strategies to Potentiate Antimicrobial Photoinactivation by Overcoming Resistant Phenotypes. Vera, D. M. A.; Haynes, M. H.; Ball, A. R.; Dai, T.; Astrakas, C.; Kelso, M. J.; Hamblin, M. R.; Tegos, G. P. Photochem. Photobiol. 2012, 88, 499–511.
  • Synthesis and Preliminary Evaluation of Amiloride Analogs as Inhibitors of the Urokinase-Type Plasminogen Activator. Matthews, H.; Ranson, M.; Tyndall, J. D. A.; Kelso, M. J. Bioorg. Med. Chem. Lett. 2011, 21, 6760-6766.
  • Small Molecule Antagonists of the Urokinase (uPA):Urokinase Receptor (uPAR) Interaction with High Reported Potencies Show Only Weak Effects in Cell-Based Competition Assays Employing the Native uPAR Ligand. De Souza, M.; Matthews, H.; Lee, J. A.; Ranson, M.; Kelso, M. J. Bioorg. Med. Chem. 2011, 19, 2549-2556.
  • Anti-Tumour/Metastasis Effects of the Potassium-Sparing Diuretic Amiloride: An Orally Active Anti-Cancer Drug Waiting for its Call-of-Duty? Matthews, H.; Ranson, M.; Kelso, M. J. Int. J. Cancer 2011, 129, 2051-2061.
  • Synthesis of Berberine−Efflux Pump Inhibitor Hybrid Antibacterials. Bremner, J. B.; Kelso, M. J. Synthetic Commun. 2010, 40, 3561-3568.
  • A Mass Spectrometric Investigation of Novel Quadruplex DNA-selective Berberine Derivatives. Gornall, K. C.; Samosorn, S.; Tanwirat, B.; Suksamrarn, A.; Bremner, J. B.; Kelso, M. J.; Beck, J. L. Chem. Commun. 2010, 46, 6602-6604.
  • Berberine−INF55 (5-Nitro-2-Phenylindole) Hybrid Antimicrobials: Effects of Varying the Relative Orientation of the Berberine and INF55 Components. Tomkiewicz, D.; Casadei, G.; Larkins-Ford, J.; Moy, T.I.; Garner, J.; Bremner, J. B.; Ausubel, F. M.; Lewis, K.; Kelso, M. J. Antimicrobial Agents and Chemother. 2010, 54, 3219-3224.
  • Inhibitors of the Plasminogen Activation System – Promising New Agents for Suppressing Breast Cancer Metastasis. Tyndall, J. D. A.; Kelso, M. J.; Ranson, M. in Frontiers in Anti-Cancer Drug Discovery 2010, 1, 55-78.
  • Linkage Isomerism in the Binding of Pentapeptide Ac-His(Ala)3His-NH2 to (Ethylenediamine)Palladium(II): Effect of the Binding Mode on Peptide Conformation. Hoang, H. N.; Bryant, G. K.; Kelso, M. J.; Beyer, R. L.   Appleton, T.  G.; Fairlie, D. P. Inorg. Chem. 2008, 47, 9439-9449.
  • Structure–Activity Relationships of 2-aryl-1H-indole Inhibitors of the NorA Efflux Pump in Staphylococcus aureus. Ambrus, J. A.; Kelso, M. J.; Bremner, J. B.; Ball, A. R.; Casadei, G.; Lewis, K. Bioorg. Med. Chem. Lett. 2008, 18, 4294-4297.
  • Oxidative Coupling of Indoles Using Thallium (III) Trifluoroacetate. Keller, P. A.; Yepuri, N. R.; Kelso, M. J.; Mariani, M.; Skelton, B. W.; White, A. H. Tetrahedron, 2008, 64, 7787-7795.
  • Peptides and Small Molecules Targeting the Plasminogen Activation System: Towards Prophylactic Anti-Metastasis Drugs for Breast Cancer. Tyndall, J. D. A.; Kelso, M. J.; Clingan, P.; Ranson, M. Recent Patents on Anti-Cancer Drug Discovery. 2008, 3, 1-13.
  • Synthesis of an Anthracyclinone Bearing an Unprecedented Aromatic Ring-Fused Bridgehead-Hydroxylated Bicyclo[3.1.1]heptanol. Kelso, C.; Beck, J.L.; Kelso, M.J. Tetrahedron Lett. 2007, 48, 7440-7443.
  • Structure-Activity Relationships of Alpha-Ketooxazole Inhibitors of Fatty Acid Amide Hydrolase. Hardouin C.; Kelso, M.J.; Romero, F.A.; Rayl, T. J.; Leung, D.; Hwang, I.; Cravatt, B. F.; Boger, D. L. J. Med. Chem. 2007, 50(14), 3359-3368.

Current GROUP MEMBERS

Postdoctoral Fellows

  • Dr Louise Whittell:  Fragment-Based Screening Approaches for New Antibiotics Directed Against the Bacterial Sliding Clamp.
  • Dr Aliluri Ramesh Reddy:  Synthesis and Biophysical Properties of Unusual Lipids found in Human Tears. 

PhD Students

  • Ben Buckley:  Inhibitors of Plasminogen Activation as Anti-Cancer/Metastasis Agents.
  • Naveen Dolla:  Dual-action hybrid antimicrobial hybrids and prodrugs, Selective antimicrobials against Clostridium difficile.
  • Nicholas Kirk:  Dual Action Angiogenesis inhibitor-Cytotoxin Prodrug Conjugates Selectivity Activated by Solid Tumour Hypoxia.
  • Alex Martyn:  Towards a Practical Total Synthesis of (R)-Telomestatin.
  • Ardeshir Rineh:  Antimicrobial Photodynamic Therapy with Phenothiazine-Efflux Pump Inhibitor Hybrids.

Honours Students

  • Thomas O'Meley:  Synthesis and Structre-Activity Relationships of Inhibitors of the Bacterial Sliding Clamp.

 Abbreviated CV

Academic Qualifications

  • B.Med. Chem. (Hons 1), University of Wollongong, 1996 (University Medal for the Faculty of Science)
  • Ph.D., Institute for Molecular Bioscience, University of Queensland, 2002 (with Professor David Fairlie)

Positions held

  • Senior Lecturer, School of Chemistry, University of Wollongong, Australia. January 2010 - Current.
  • Lecturer, School of Chemistry, University of Wollongong, Australia.  January 2008-2009.
  • NHMRC CJ Martin Research Fellow, School of Chemistry, University of Wollongong, Australia. January 2006 - January 2008.
  • NHMRC CJ Martin Research Fellow, Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA (with Professor Dale Boger) January 2004 - December 2005.
  • Postdoctoral Research Fellow, Universidad del Pais Vasco, San Sebastian, Spain (with Professor Claudio Palomo and Professor Mikel Oiarbide) December 2002 - December 2003.
  • Postdoctoral Research Fellow, Institute for Molecular Bioscience, University of Queensland (with Professor David Fairlie) March 2002 - November 2002.
Last reviewed: 9 December, 2015